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Literature summary for 4.3.2.1 extracted from
- On the role of substrate and GTP in the regulation of argininosuccinase activity (1975), J. Biol. Chem., 250, 7225-72300.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| GTP | 0.2 mM, stimulates | Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.037 | - |
argininosuccinate | Km-value at low concentrations of argininosuccinate | Bos taurus | |
| 0.16 | - |
argininosuccinate | Km-value at high concentrations of argininosuccinate | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | metabolic role in biosynthesis of Arg and urea | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| argininosuccinate | - |
Bos taurus | fumarate + L-Arg | - |
? | |
| additional information | metabolic role in biosynthesis of Arg and urea | Bos taurus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| GDP | 0.2 mM, slight stimulation | Bos taurus | |
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Release 2023.1 (January 2023)
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