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Literature summary for 4.3.3.7 extracted from

  • Pearce, F.G.; Perugini, M.A.; McKerchar, H.J.; Gerrard, J.A.
    Dihydrodipicolinate synthase from Thermotoga maritima (2006), Biochem. J., 400, 359-366.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.3.7

Cloned(Commentary)

Cloned (Comment) Organism
-
 Thermotoga maritima

Crystallization (Commentary)

Crystallization (Comment) Organism
the X-ray crystal structure is described Thermotoga maritima

Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibited by (S)-lysine, suggesting that feedback control of the lysine biosynthetic pathway evolves later in the bacterial lineage Thermotoga maritima

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
33800
-
 4 * 33800, calculated from sequence Thermotoga maritima
133000
-
 sedimentation equilibrium analysis Thermotoga maritima

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(S)-aspartate 4-semialdehyde + pyruvate Thermotoga maritima catalyses the branch point in lysine biosynthesis dihydrodipicolinate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Thermotoga maritima Q9X1K9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Thermotoga maritima

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-aspartate 4-semialdehyde + pyruvate catalyses the branch point in lysine biosynthesis Thermotoga maritima dihydrodipicolinate + H2O
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 33800, calculated from sequence Thermotoga maritima

Synonyms

Synonyms Comment Organism
DHDPS
-
 Thermotoga maritima

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
90
-
 7 h, 40% loss of activity. When the enzyme is incubated at 90°C in 8M urea, 60% of the activity is lost after 90 min Thermotoga maritima