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Literature summary for 4.4.1.1 extracted from
- Cystathionine gamma-lyase from Streptomyces phaeochromogenes (1987), Methods Enzymol., 143, 486-492.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cycloserine | D-cycloserine | Streptomyces phaeochromogenes |  |
| hydroxylamine | - |
Streptomyces phaeochromogenes | |
| Penicillamine | D-penicillamine; L-penicillamine | Streptomyces phaeochromogenes | |
| phenylhydrazine | - |
Streptomyces phaeochromogenes | |
| Semicarbazide | - |
Streptomyces phaeochromogenes | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 166000 | - |
- |
Streptomyces phaeochromogenes |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces phaeochromogenes | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces phaeochromogenes |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.6 | - |
- |
Streptomyces phaeochromogenes |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, 10 mM potassium phosphate, pH 7.5, containing 0.02 mM pyridoxal phosphate, 0.12 mM EDTA, 0.2 mM dithiothreitol stable for 2 weeks | Streptomyces phaeochromogenes |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-Cys + L-homoserine | gamma-replacement | Streptomyces phaeochromogenes | D-allocystathionine | - |
? | |
| L-cystathionine + H2O | alpha,gamma-elimination | Streptomyces phaeochromogenes | L-cysteine + 2-oxobutanoate + NH3 | - |
? | |
| L-homoserine | alpha,gamma-elimination | Streptomyces phaeochromogenes | ? | - |
? | |
| L-homoserine + 2-mercaptopropionate | gamma-replacement reaction | Streptomyces phaeochromogenes | S-methylcarboxymethyl-L-homocysteine | - |
? | |
| L-homoserine + 3-mercaptopropionate | gamma-replacement reaction | Streptomyces phaeochromogenes | S-carboxyethyl-L-homocysteine | - |
? | |
| L-homoserine + L-Cys | - |
Streptomyces phaeochromogenes | L-cystathionine | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
alpha,gamma-elimination of L-cystathionine and L-homoserine | Streptomyces phaeochromogenes |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
alpha,gamma-elimination of L-cystathionine and L-homoserine | Streptomyces phaeochromogenes |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | contains 4 mol of pyridoxal 5'-phosphate per mol of enzyme | Streptomyces phaeochromogenes | |
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Release 2023.1 (January 2023)
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