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Literature summary for 4.4.1.13 extracted from
- Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity (1985), J. Biol. Chem., 260, 7945-7950.
General Stability
| General Stability | Organism |
|---|---|
| pyridoxal 5'-phosphate stabilizes | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-hydroxykynurenine | cysteine conjugate beta-lyase activity | Rattus norvegicus |  |
| hydroxylamine | - |
Rattus norvegicus | |
| KCN | - |
Rattus norvegicus | |
| kynurenine | cysteine conjugate beta-lyase activity | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.013 | - |
3-hydroxy-kynurenine | - |
Rattus norvegicus | |
| 0.4 | - |
kynurenine | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 55000 | - |
2 * 55000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0817 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxykynurenine | - |
Rattus norvegicus | ? | - |
? | |
| kynurenine | - |
Rattus norvegicus | ? | - |
? | |
| xenobiotics | - |
Rattus norvegicus | thiol + pyruvate + NH3 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 55000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | rat liver enzyme: same enzyme as kynureninase | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 70 | - |
50% loss of activity after 10 min | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Rattus norvegicus | |
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