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Literature summary for 4.4.1.13 extracted from

  • Burnell, J.N.; Whatley, F.R.
    Sulphur metabolism in Paracoccus denitrificans. Purification, properties and regulation of serine transacetylase, O-acetylserine sulphydrylase and beta-cystathionase (1977), Biochim. Biophys. Acta, 481, 246-265.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Cys strong Paracoccus denitrificans
glutathione strong Paracoccus denitrificans
homocysteine strong Paracoccus denitrificans
hydroxylamine
-
 Paracoccus denitrificans
iodoacetamide
-
 Paracoccus denitrificans
KCN
-
 Paracoccus denitrificans
NaF 10 mM, weak Paracoccus denitrificans
NEM
-
 Paracoccus denitrificans
O-acetylserine strong Paracoccus denitrificans
PCMB
-
 Paracoccus denitrificans
phenylhydrazine
-
 Paracoccus denitrificans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.2
-
 cystathionine
-
 Paracoccus denitrificans

Organism

Organism UniProt Comment Textmining
Paracoccus denitrificans
-
-
-
Paracoccus denitrificans 8944
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Paracoccus denitrificans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cystathionine + H2O
-
 Paracoccus denitrificans L-homocysteine + NH3 + pyruvate
-
 ?
L-cystathionine + H2O
-
 Paracoccus denitrificans 8944 L-homocysteine + NH3 + pyruvate
-
 ?
L-cystine + H2O 28% of the activity with L-cystathionine Paracoccus denitrificans L-thiocysteine + pyruvate + NH3
-
 ?
L-cystine + H2O 28% of the activity with L-cystathionine Paracoccus denitrificans 8944 L-thiocysteine + pyruvate + NH3
-
 ?
L-djenkolate + H2O 79% of the activity with L-cystathionine Paracoccus denitrificans pyruvate
-
 ?
L-djenkolate + H2O 79% of the activity with L-cystathionine Paracoccus denitrificans 8944 pyruvate
-
 ?
L-homocysteine + H2O 5% of the activity with L-cystathionine Paracoccus denitrificans ?
-
 ?
L-homocysteine + H2O 5% of the activity with L-cystathionine Paracoccus denitrificans 8944 ?
-
 ?
lanthionine + H2O DL-lanthionine, 136% of the activity with L-cystathionine Paracoccus denitrificans L-cysteine + NH3 + pyruvate
-
 ?
lanthionine + H2O DL-lanthionine, 136% of the activity with L-cystathionine Paracoccus denitrificans 8944 L-cysteine + NH3 + pyruvate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9 9.5
-
 Paracoccus denitrificans

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required as cofactor Paracoccus denitrificans