Activating Compound | Comment | Organism | Structure |
---|---|---|---|
alpha-Keto acids | restore activity during reaction | Sus scrofa |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-cysteine | competitive | Sus scrofa |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.52 | - |
L-selenocysteine | pH 8.5 | Sus scrofa |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-selenocysteine + reduced acceptor | Sus scrofa | - |
selenide + L-alanine + acceptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Sus scrofa |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Sus scrofa | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-selenocysteine + reduced acceptor | - |
Sus scrofa | selenide + L-alanine + acceptor | - |
? | |
L-selenocysteine + reduced acceptor | enzyme bound pyridoxal 5'-phosphate serves as acceptor | Sus scrofa | selenide + L-alanine + acceptor | enzyme bound pyridoxamine 5'-phosphate formed during reaction, regeneration of enzyme by addition of an alpha-keto acid | ? | |
L-selenocysteine + reduced acceptor | enzyme bound pyridoxal 5'-phosphate serves as acceptor | Sus scrofa | selenide + L-alanine + acceptor | formation of H2Se by nonenzymatic reduction of elemental selenium in presence of dithiothreitol | ? | |
L-selenocysteine + reduced acceptor | enzyme is inativated during course of reaction without addition of pyridoxal 5'-phosphate | Sus scrofa | selenide + L-alanine + acceptor | enzyme bound pyridoxamine 5'-phosphate formed during reaction, regeneration of enzyme by addition of an alpha-keto acid | ? | |
L-selenocysteine + reduced acceptor | enzyme is inativated during course of reaction without addition of pyridoxal 5'-phosphate | Sus scrofa | selenide + L-alanine + acceptor | formation of H2Se by nonenzymatic reduction of elemental selenium in presence of dithiothreitol | ? | |
additional information | no activity with L-cysteine | Sus scrofa | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | required | Sus scrofa |