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Literature summary for 4.4.1.16 extracted from

  • Esaki, N.; Karai, N.; Nakamura, T.; Tanaka, H.; Soda, K.
    Mechanism of reactions catalyzed by selenocysteine beta-lyase (1985), Arch. Biochem. Biophys., 238, 418-423.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
alpha-Keto acids restore activity during reaction Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
L-cysteine competitive Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.52
-
L-selenocysteine pH 8.5 Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-selenocysteine + reduced acceptor Sus scrofa
-
selenide + L-alanine + acceptor
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-selenocysteine + reduced acceptor
-
Sus scrofa selenide + L-alanine + acceptor
-
?
L-selenocysteine + reduced acceptor enzyme bound pyridoxal 5'-phosphate serves as acceptor Sus scrofa selenide + L-alanine + acceptor enzyme bound pyridoxamine 5'-phosphate formed during reaction, regeneration of enzyme by addition of an alpha-keto acid ?
L-selenocysteine + reduced acceptor enzyme bound pyridoxal 5'-phosphate serves as acceptor Sus scrofa selenide + L-alanine + acceptor formation of H2Se by nonenzymatic reduction of elemental selenium in presence of dithiothreitol ?
L-selenocysteine + reduced acceptor enzyme is inativated during course of reaction without addition of pyridoxal 5'-phosphate Sus scrofa selenide + L-alanine + acceptor enzyme bound pyridoxamine 5'-phosphate formed during reaction, regeneration of enzyme by addition of an alpha-keto acid ?
L-selenocysteine + reduced acceptor enzyme is inativated during course of reaction without addition of pyridoxal 5'-phosphate Sus scrofa selenide + L-alanine + acceptor formation of H2Se by nonenzymatic reduction of elemental selenium in presence of dithiothreitol ?
additional information no activity with L-cysteine Sus scrofa ?
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate required Sus scrofa