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Literature summary for 4.4.1.20 extracted from

  • Söderström, M.; Mannervik, B.; Garkov, V.; Hammarström, S.
    On the nature of leukotriene C4 synthase in human platelets (1992), Arch. Biochem. Biophys., 294, 70-74.
    View publication on PubMed
Search for more literature for 4.4.1.20

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.007
-
 leukotriene A4 pH 6.5, 30°C Homo sapiens
0.015
-
 leukotriene A4 methyl ester pH 6.5, 30°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane associated with Homo sapiens 16020
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
platelet
-
 Homo sapiens
-

Storage Stability

Storage Stability Organism
-20°C, enzyme in the membrane fraction from human platelets can be stored without major loss of activity Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
 Homo sapiens leukotriene C4 + H2O
-
 ?
leukotriene A4 methyl ester + glutathione 6.5% of the activity with leukotriene A4 Homo sapiens leukotriene C4 methyl ester + H2O
-
 ?
leukotriene A4 methyl ester + glutathione
-
 Homo sapiens leukotriene C4 methyl ester
-
 ?
leukotriene A5 + glutathione 37% of the activity with leukotriene A4 Homo sapiens ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 8.8 pH 5.5: about 25% of maximal activity, pH 8.8: about 45% of maximal activity Homo sapiens