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Literature summary for 4.4.1.20 extracted from
- Location, location, location: compartmentalization of early events in leukotriene biosynthesis (2010), J. Biol. Chem., 285, 25109-25114.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| X-ray structure refined to 2.15 A resolution | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| leukotriene C4 | leukotriene C4 accumulation inhibits LTC4 synthase activity | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | is localized to the outer nuclear membrane, is associated with 5-lipoxygenase activating protein and 5-lipoxygenase. Exclusion from the inner nuclear membrane | Homo sapiens | 16020 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16873 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| trimer | crystallography | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| leukotriene C4 synthase | - |
Homo sapiens |
| LTC4S | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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