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Literature summary for 4.4.1.20 extracted from

  • Di Gennaro, A.; Wagsaeter, D.; Maeyraenpaeae, M.I.; Gabrielsen, A.; Swedenborg, J.; Hamsten, A.; Samuelsson, B.; Eriksson, P.; Haeggstroem, J.Z.
    Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm (2010), Proc. Natl. Acad. Sci. USA, 107, 21093-21097.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine mRNA levels for the three key enzymes/proteins in the biosynthesis of cysteinyl-leukotrienes, 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase, are significantly increased in the wall of human abdominal aortic aneurysm. Immunohistochemical staining reveals focal expression of 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase proteins in the media and adventitia, localized in areas rich in inflammatory cells, including macrophages, neutrophils, and mast cells. Challenge of abdominal aortic aneurysm wall tissue with exogenous LTD4 increases the release of matrix metalloproteinases 2 and 9, and selective inhibition of the CysLT1 receptor by montelukast blocks this effect Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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 patients with abdominal aortic aneurysm
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Source Tissue

Source Tissue Comment Organism Textmining

Expression

Organism Comment Expression
Homo sapiens mRNA levels for the three key enzymes/proteins in the biosynthesis of cysteinyl-leukotrienes, 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase, are significantly increased in the wall of human abdominal aortic aneurysm up