Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | a nuclear membrane enzyme | Homo sapiens | 16020 | - |
nucleus | a nuclear membrane enzyme | Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + glutathione | Homo sapiens | - |
leukotriene C4 | a cysteinyl leukotriene | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
leukotriene C4 = leukotriene A4 + glutathione | the thiolate of glutathione acts as a nucleophile attacking C6 of leukotriene A4 forming a S-C6 bond, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen resulting in opening of the epoxide ring and stabilization of the LTC4 product complex. The tail-to-head orientation appears to be the most likely substrate orientation | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
leukotriene A4 + glutathione | - |
Homo sapiens | leukotriene C4 | a cysteinyl leukotriene | ? | |
leukotriene A4 + glutathione | mechanism of leukotriene A4 binding, docking and molecular dynamics simulations using the enzyme crystal structure, PDB ID 2PNO, overview | Homo sapiens | leukotriene C4 | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | the enzyme exists as a trimer, where the active site is formed at the interface of two of the three monomers | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
leukotriene C4 synthase | - |
Homo sapiens |
LTC4S | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | leukotrienes are a family of drug-like molecules involved in the pathobiology of bronchial asthma and are responsible for smooth muscle contraction | Homo sapiens |