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Literature summary for 4.4.1.20 extracted from

  • MacDonald, C.A.; Bushnell, E.A.; Gauld, J.W.; Boyd, R.J.
    The catalytic formation of leukotriene C4: a critical step in inflammatory processes (2014), Phys. Chem. Chem. Phys., 16, 16284-16289.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane a nuclear membrane enzyme Homo sapiens 16020
-
nucleus a nuclear membrane enzyme Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
leukotriene A4 + glutathione Homo sapiens
-
leukotriene C4 a cysteinyl leukotriene ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
leukotriene C4 = leukotriene A4 + glutathione the thiolate of glutathione acts as a nucleophile attacking C6 of leukotriene A4 forming a S-C6 bond, a proton is transferred from the guanidinium of Arg31 to the epoxide ring oxygen resulting in opening of the epoxide ring and stabilization of the LTC4 product complex. The tail-to-head orientation appears to be the most likely substrate orientation Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
leukotriene A4 + glutathione
-
Homo sapiens leukotriene C4 a cysteinyl leukotriene ?
leukotriene A4 + glutathione mechanism of leukotriene A4 binding, docking and molecular dynamics simulations using the enzyme crystal structure, PDB ID 2PNO, overview Homo sapiens leukotriene C4
-
?

Subunits

Subunits Comment Organism
trimer the enzyme exists as a trimer, where the active site is formed at the interface of two of the three monomers Homo sapiens

Synonyms

Synonyms Comment Organism
leukotriene C4 synthase
-
Homo sapiens
LTC4S
-
Homo sapiens

General Information

General Information Comment Organism
physiological function leukotrienes are a family of drug-like molecules involved in the pathobiology of bronchial asthma and are responsible for smooth muscle contraction Homo sapiens