Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2,2-diethyl-1-nitroso-oxyhydrazine | 0.1 mM, 87fold increase in activity, NO-relasing substance | Homo sapiens | |
NO | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in Sf9 insect cells | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.057 | - |
GTP | in the presence of NO | Homo sapiens | |
0.19 | - |
GTP | in the absence of NO | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
1 * 72000 + 1 * 80000, SDS-PAGE | Homo sapiens |
80000 | - |
1 * 72000 + 1 * 80000, SDS-PAGE | Homo sapiens |
160000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
Q-Sepharose, Blue-Sepharose, hydroxyapatite, gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
platelet | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.034 | - |
basal activity in the absence of NO | Homo sapiens |
2.96 | - |
in the presence of 0.1 mM 2,2-diethyl-1-nitroso-oxyhydrazine as NO source | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 72000 + 1 * 80000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
nitric oxid sensitive guanylyl cyclase | - |
Homo sapiens |
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |