Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.6.1.2 extracted from

  • Schmidt, P.; Schramm, M.; Schroder, H.; Stasch, J.P.
    Mechanisms of nitric oxide independent activation of soluble guanylyl cyclase (2003), Eur. J. Pharmacol., 468, 167-174.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5(4-morpholinyl)-4,6-pyrimidinediamine trivial name BAY 41-8543, 66fold activation at 0.1 mM, strong synergistic activation in the presence of NO Homo sapiens
4-[((4-carboxybutyl){2-[(4-phenethylbenzol)oxy]phenethyl}amino)methyl] benzoic acid trivial name BAY 58-2667, heme-independent activator, 30fold activation at 0.01 mM Homo sapiens
NO
-
Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Sf9 insect cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1H-(1,2,4)-oxadiazole-(4,3-a)quinoxalin-1-one
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.074
-
GTP at the basal state of sGC Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Homo sapiens
-
3',5'-cyclic GMP + diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
Homo sapiens 3',5'-cyclic GMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
soluble guanylyl cyclase
-
Homo sapiens