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Literature summary for 4.6.1.2 extracted from
- Soluble guanylate cyclase (2006), Curr. Opin. Struct. Biol., 16, 736-743.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| NO | beta2 homodimer forms a five-coordinate Fe(II)-NO-complex | Rattus norvegicus |  |
| NO | H-NOX has a very high affinity for NO, with a Kd in the femtomolar range, NO complex wiht H-NOX is very stable, five-coordinate NO complex | Clostridium botulinum | |
| NO | perfect heme ligand, serves as an effector of enzyme activation via conformational transitions | Homo sapiens | |
| NO | perfect heme ligand, serves as an effector of enzyme activation via conformational transitions | Bos taurus | |
| O2 | H-NOX forms/does not form a stable O2 complex at 70°C, diverging studies | Caldanaerobacter subterraneus subsp. tengcongensis | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| beta1 (residues 1-194) and beta2 (residues 1-217) homodimers expressed in Escherichia coli | Rattus norvegicus |
| by baculovirus expression system | Homo sapiens |
| expressed in Escherichia coli | Clostridium botulinum |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| to 1.77 A and 2.5 A resolution, N-terminal heme domain and C-terminal catalytic domain | Caldanaerobacter subterraneus subsp. tengcongensis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | beta2 homodimer forms a five-coordinate Fe(II)-NO-complex | Rattus norvegicus | |
| Fe2+ | ligands of the form XO can bind to the heme Fe in either a linear or bent configuration | Homo sapiens | |
| Fe2+ | ligands of the form XO can bind to the heme Fe in either a linear or bent configuration | Bos taurus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Caldanaerobacter subterraneus subsp. tengcongensis | - |
- |
- |
| Clostridium botulinum | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Vibrio cholerae serotype O1 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lung | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homodimer | - |
Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| H-NOX | - |
Clostridium botulinum |
| H-NOX | - |
Caldanaerobacter subterraneus subsp. tengcongensis |
| sGC | - |
Homo sapiens |
| sGC | - |
Rattus norvegicus |
| sGC | - |
Bos taurus |
| sGC | - |
Vibrio cholerae serotype O1 |
| sGC | - |
Clostridium botulinum |
| sGC | - |
Caldanaerobacter subterraneus subsp. tengcongensis |
| soluble guanylate cyclase | - |
Homo sapiens |
| soluble guanylate cyclase | - |
Rattus norvegicus |
| soluble guanylate cyclase | - |
Bos taurus |
| soluble guanylate cyclase | - |
Vibrio cholerae serotype O1 |
| soluble guanylate cyclase | - |
Clostridium botulinum |
| soluble guanylate cyclase | - |
Caldanaerobacter subterraneus subsp. tengcongensis |
| SONO | - |
Clostridium botulinum |
| SONO | - |
Caldanaerobacter subterraneus subsp. tengcongensis |
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