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Literature summary for 4.6.1.2 extracted from

  • Zhou, Z.; Sayed, N.; Pyriochou, A.; Roussos, C.; Fulton, D.; Beuve, A.; Papapetropoulos, A.
    Protein kinase G phosphorylates soluble guanylyl cyclase on serine 64 and inhibits its activity (2008), Arterioscler. Thromb. Vasc. Biol., 28, 1803-1810.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
NO binds and activates the enzyme Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression of alpha1 and beta1 subunits and mutant enzyme in COSm6 and A7r5 smooth muscle cells Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
S64A an alpha1/beta1 sGC mutant, shows resistance to phosphorylation by the cGMP-dependent protein kinase Rattus norvegicus
S64D an alpha1/beta1 sGC mutant, is less activated by NO in comparison to the wild-type enzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphorylation at Ser64 of the alpha1 subunit inhibits the enzyme Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus the cGMP-dependent protein kinase negatively regulates sGC activity, phosphorylation at Ser64 desensitizes sGC and dampens NO signaling, overview 3',5'-cyclic GMP + diphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein sGC is phosphorylated at Ser64 of the alpha1 subunit by the cGMP-dependent protein kinase, which leads to sGC inhibition, no phosphorylation of the enzyme mutant S64A alpha1/beta1 sGC, mutational determination of the phosphorylation site, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
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 ?
GTP the cGMP-dependent protein kinase negatively regulates sGC activity, phosphorylation at Ser64 desensitizes sGC and dampens NO signaling, overview Rattus norvegicus 3',5'-cyclic GMP + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
sGC
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 Rattus norvegicus