Activating Compound | Comment | Organism | Structure |
---|---|---|---|
BAY 41-2272 | heme-dependent sGC activator | Homo sapiens | |
meso-porphyrin IX | heme-independent activator | Homo sapiens | |
nitric oxide | stimulates activity if sGC, 2.2 nM thrombospondin-1 binds to CD47 and potently inhibits nitric oxide stimulation of sGC | Homo sapiens | |
YC-1 | heme-dependent sGC activator | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
thrombospondin-1 | thrombospondin-1 is a universal inhibitor of sGC, blocking both hemedependent and heme-independent activation | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | Homo sapiens | - |
3',5'-cyclic-GMP + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | - |
Homo sapiens | - |
blood vessel endothelium | - |
Homo sapiens | - |
vascular smooth muscle cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP | - |
Homo sapiens | 3',5'-cyclic-GMP + diphosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sGC | - |
Homo sapiens |
soluble guanylyl cyclase | - |
Homo sapiens |