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Literature summary for 4.6.1.2 extracted from
- Direct fusion of subunits of heterodimeric nitric oxide sensitive guanylyl cyclase leads to functional enzymes with preserved biochemical properties: evidence for isoform specific activation by ciguates (2010), Biochem. Pharmacol., 80, 1676-1683.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ataciguat | HMR 1766 | Rattus norvegicus |  |
| cinaciguat | BAY 58-2667 | Rattus norvegicus | |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Sf9 insect cells | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| nitric oxide | - |
Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 70400 | - |
1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
| 72000 | - |
1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
| 78600 | - |
1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
| 80000 | - |
1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
| 150000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Strep-Tactin1 Superflow column chromatography, Mono Q column chromatography | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP | - |
Rattus norvegicus | 3',5'-cyclic-GMP + diphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 78600 + 1 * 70400, calculated from amino acid sequence | Rattus norvegicus |
| heterodimer | 1 * 80000 + 1 * 72000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nitric oxide sensitive guanylyl cyclase | - |
Rattus norvegicus |
| NO sensitive guanylyl cyclase | - |
Rattus norvegicus |
| NOsGC | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | nitric oxide sensitive guanylyl cyclase is the major physiological receptor for nitric oxide throughout the cardiovascular and central nervous system | Rattus norvegicus |
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Release 2023.1 (January 2023)
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