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Literature summary for 4.6.1.2 extracted from

  • Baskaran, P.; Heckler, E.J.; van den Akker, F.; Beuve, A.
    Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity (2011), PLoS ONE, 6, e26976.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.6.1.2

Activating Compound

Activating Compound Comment Organism Structure
nitric oxide
-
 Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
E138A the mutant is less responsive to nitric oxide in comparison to the wild type enzyme Rattus norvegicus
G114A the mutant has characteristics similar to the wild type enzyme Rattus norvegicus
I111A the mutant has a decreased basal activity and is less responsive to activators in comparison to the wild type enzyme Rattus norvegicus
I41A the mutant is strongly activated by YC-1, nitric oxide and to a lesser extent by protoporphyrin IX Rattus norvegicus
R40A the mutation results in a drastic decrease not only in basal activity but also in stimulated activity in response to protoporphyrin IX, YC-1, nitric oxide Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP Rattus norvegicus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P20595
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP
-
 Rattus norvegicus 3',5'-cyclic GMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
heterodimer
-
 Rattus norvegicus

Synonyms

Synonyms Comment Organism
sGC
-
 Rattus norvegicus
soluble guanylyl cyclase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
heme
-
 Rattus norvegicus