Literature summary for 5.1.1.11 extracted from

Stein, T.; Kluge, B.; Vater, J.; Franke, P.; Otto, A.; Wittmann-Liebold, B.
Gramicidin S synthetase 1 (phenylalanine racemase), a prototype of amino acid racemase containing the cofactor 4'-phosphopantetheine (1995), Biochemistry, 34, 4633-4642.

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Organism

Organism	UniProt	Comment	Textmining
Brevibacillus brevis	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + L-phenylalanine + H2O = AMP + diphosphate + D-phenylalanine	racemizes Phe in the thioester-bound stage	Brevibacillus brevis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-Phe + H2O	-	Brevibacillus brevis	AMP + diphosphate + D-Phe	-	?

Cofactor

Cofactor	Comment	Organism	Structure
4'-phosphopantetheine	a 4'-phosphopantetheine carrier is found to be attached to the active site Ser of the consensus motif LGGDSI forming the thiolation site of Phe	Brevibacillus brevis

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Release 2023.1 (January 2023)