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Literature summary for 5.2.1.8 extracted from

  • Carpentier, M.; Allain, F.; Haendler, B.; Slomianny, M.C.; Spik, G.
    Delineation of the calcineurin-interacting region of cyclophilin B (2000), Protein Sci., 9, 2386-2393.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
D155R mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity Homo sapiens
D158R mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity Homo sapiens
G77H mutant enzyme has intact isomerase activity and cyclosporin A-binding activity. When complexed to cyclosporin A, the mutant enzyme displays only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information cyclophilin B complexed to cyclosporin A inhibits phosphatase activity of recombinant human calcineurin Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Cyclophilin B
-
 Homo sapiens
CyPB
-
 Homo sapiens