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Literature summary for 5.2.1.8 extracted from
- Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis (2004), Biochem. J., 383, 101-109.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | enzyme overexpression renders isolated mitochondria far more susceptible to the permeability transition induced by Ca2+ and oxidative stress. Overexpressing cells maintain a lower inner-membrane potential of mitochondria than those of normal cells. Effects are abolished by cyclosporin A. Cyclosporin-D overexpression promotes NO-induced necrosis and inhibits staurosporine-induced apoptosis | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | matrix | Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| B-50 cell | neuronal cell line | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclophilin-D | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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