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Literature summary for 5.2.1.8 extracted from

  • Leuzzi, R.; Serino, L.; Scarselli, M.; Savino, S.; Fontana, M.R.; Monaci, E.; Taddei, A.; Fischer, G.; Rappuoli, R.; Pizza, M.
    Ng-MIP, a surface-exposed lipoprotein of Neisseria gonorrhoeae, has a peptidyl-prolyl cis/trans isomerase (PPIase) activity and is involved in persistence in macrophages (2005), Mol. Microbiol., 58, 669-681.
    View publication on PubMed
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information enzyme deletion mutant, enzyme is not required in log phase of growth. Mutation does not affect the binding of strain to macrophages but decreases intracellular survival in macrophages Neisseria gonorrhoeae

Inhibitors

Inhibitors Comment Organism Structure
Rapamycin 50% inhibition at 5 nM Neisseria gonorrhoeae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane surface-exposed Neisseria gonorrhoeae 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28908
-
 x * 28908, calculated Neisseria gonorrhoeae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Neisseria gonorrhoeae protein is not involved in binding to macrophages and does not impair the ability of macrophages to phagocytose the gonococci ?
-
 ?

Organism

Organism UniProt Comment Textmining
Neisseria gonorrhoeae
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
lipoprotein
-
 Neisseria gonorrhoeae

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information protein is not involved in binding to macrophages and does not impair the ability of macrophages to phagocytose the gonococci Neisseria gonorrhoeae ?
-
 ?
succinyl-Ala-Ala-(cis)-Pro-Phe-p-nitroanilide 70fold decrease in activity compared with succinyl-Ala-Phe-(cis)-Pro-Phe-p-nitroanilide Neisseria gonorrhoeae succinyl-Ala-Ala-(trans)-Pro-Phe-p-nitroanilide
-
 ?
succinyl-Ala-Phe-(cis)-Pro-Phe-p-nitroanilide
-
 Neisseria gonorrhoeae succinyl-Ala-Phe-(trans)-Pro-Phe-p-nitroanilide
-
 ?

Subunits

Subunits Comment Organism
? x * 28908, calculated Neisseria gonorrhoeae

Synonyms

Synonyms Comment Organism
Ng-MIP
-
 Neisseria gonorrhoeae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
 additional information ratio of kcat/Km-value is 410000 per M and s Neisseria gonorrhoeae