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Literature summary for 5.2.1.8 extracted from

  • Halt, D.A.; Konialian-Beck, A.L.; Oh, H.J.; Yen, H.K.; Rozamus, L.W.; Krog, A.J.; Erhard, K.F.; Ortiz, E.; Levy, M.A.; Brandt, M.; Bossard, M.; Luengo, J.I.
    Structure-activity studies of synthetic FKBP ligands as peptidyl-prolyl isomerase inhibitors (1994), Bioorg. Med. Chem. Lett., 4, 315-322.
No PubMed abstract available
Search for more literature for 5.2.1.8

Inhibitors

Inhibitors Comment Organism Structure
(1R)-1,3-diphenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-1-cyclohexyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-1-naphthalen-2-yl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-3-(1,3-benzodioxol-5-yl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-3-cyclohexyl-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
(1R)-3-cyclohexyl-1-phenylpropyl 1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
(1S)-1,3-diphenylpropyl 1-(benzylsulfonyl)piperidine-2-carboxylate
-
 Homo sapiens
(1S)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethylbutanoyl)piperidine-2-carboxylate
-
 Homo sapiens
1-benzyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
3-(3,4,5-trimethoxyphenyl)propyl 1-(benzylsulfonyl)piperidine-2-carboxylate
-
 Homo sapiens
3-phenylpropyl 1-(2-hydroxy-3,3-dimethylpentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl (2S)-1-(4,4-dimethyl-2-oxohexanoyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl (2S)-1-[(2-methoxycyclohexyl)(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
ethyl (2S)-1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
ethyl 1-(4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl 1-(4-methyl-2-oxopentanethioyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl 1-(4-methyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl 1-(5-ethoxy-4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
ethyl 1-[(1-methoxycyclohexyl)(oxo)acetyl]pyrrolidine-2-carboxylate
-
 Homo sapiens
ethyl 1-[(3-methoxytetrahydro-2H-pyran-2-yl)(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00016
-
 (1S)-1,3-diphenylpropyl 1-(benzylsulfonyl)piperidine-2-carboxylate
-
 Homo sapiens
0.0002
-
 (1S)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethylbutanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.00023
-
 3-(3,4,5-trimethoxyphenyl)propyl 1-(benzylsulfonyl)piperidine-2-carboxylate
-
 Homo sapiens
0.00066
-
 ethyl (2S)-1-(4,4-dimethyl-2-oxohexanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.001
-
 ethyl (2S)-1-[(2-methoxycyclohexyl)(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
0.001
-
 ethyl 1-(5-ethoxy-4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.002
-
 ethyl (2S)-1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
0.002
-
 ethyl 1-(4-methyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.002
-
 ethyl 1-(4,4-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.002 0.006 (1R)-3-(3,4-dimethoxyphenyl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.0023
-
 3-phenylpropyl 1-(2-hydroxy-3,3-dimethylpentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.004
-
 ethyl 1-[(3-methoxytetrahydro-2H-pyran-2-yl)(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
0.004 0.01 (1R)-1-naphthalen-2-yl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.0043
-
 ethyl 1-(4-methyl-2-oxopentanethioyl)piperidine-2-carboxylate
-
 Homo sapiens
0.007
-
 (1R)-1-cyclohexyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.008
-
 ethyl 1-[(1-methoxycyclohexyl)(oxo)acetyl]pyrrolidine-2-carboxylate
-
 Homo sapiens
0.009
-
 (1R)-1-phenyl-3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.009
-
 (1R)-3-(1,3-benzodioxol-5-yl)-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.01
-
 (1R)-1,3-diphenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.01
-
 (1R)-3-cyclohexyl-1-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.012
-
 3-(3,4,5-trimethoxyphenyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens
0.02
-
 (1R)-3-cyclohexyl-1-phenylpropyl 1-[cyclohexyl(oxo)acetyl]piperidine-2-carboxylate
-
 Homo sapiens
0.055
-
 1-benzyl-3-phenylpropyl 1-(3,3-dimethyl-2-oxopentanoyl)piperidine-2-carboxylate
-
 Homo sapiens