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Literature summary for 5.2.1.8 extracted from

  • Erben, E.D.; Daum, S.; Tellez-Inon, M.T.
    The Trypanosoma cruzi PIN1 gene encodes a parvulin peptidyl-prolyl cis/trans isomerase able to replace the essential ESS1 in Saccharomyces cerevisiae (2007), Mol. Biochem. Parasitol., 153, 186-193.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
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Trypanosoma cruzi

Protein Variants

Protein Variants Comment Organism
additional information enzyme is able to replace the essential homolog Ess1 in Saccharomyces cerevisiae Trypanosoma cruzi

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13000
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x * 13000, SDS-PAGE Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi Q2I5R9 isoform PIN1, parvulin-type, present in both dividing and non-dividing forms
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Source Tissue

Source Tissue Comment Organism Textmining
epimastigote neither cell growth kinetics nor cell morphology are affected by the overexpression of Pin1 Trypanosoma cruzi
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
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Trypanosoma cruzi N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide ratio kcat to Km value is 15400 per M and s ?
N-succinyl-Ala-Glu-(trans)-Pro-Phe-4-nitroanilide
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Trypanosoma cruzi N-succinyl-Ala-Glu-(cis)-Pro-Phe-4-nitroanilide ratio kcat to Km value is 397000 per M and s ?

Subunits

Subunits Comment Organism
? x * 13000, SDS-PAGE Trypanosoma cruzi