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Literature summary for 5.2.1.8 extracted from

  • Kuboki, S.; Sakai, N.; Clarke, C.; Schuster, R.; Blanchard, J.; Edwards, M.J.; Lentsch, A.B.
    The peptidyl-prolyl isomerase, Pin1, facilitates NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury (2009), J. Hepatol., 51, 296-306.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Protein Variants

Protein Variants Comment Organism
additional information Pin1 knockout mice show reduced neutrophile accumulation in the liver, reduced NF-kappaB activation, and increased nuclear p65 protein expression compared to wild-type mice, phenotypes, overview Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57BJ/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
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Kupffer cell
-
 Mus musculus
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liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
peptidyl-prolyl isomerase
-
 Mus musculus
Pin1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function peptidyl-prolyl isomerase, Pin1, is a critical regulator of NF-kappaB activation facilitating NF-kappaB binding in hepatocytes and protects against hepatic ischemia/reperfusion injury. Pin1 is required for full production of MIP-2, but not for production of TNFalpha Mus musculus