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Literature summary for 5.2.1.8 extracted from

  • Nakatsu, Y.; Sakoda, H.; Kushiyama, A.; Zhang, J.; Ono, H.; Fujishiro, M.; Kikuchi, T.; Fukushima, T.; Yoneda, M.; Ohno, H.; Horike, N.; Kanna, M.; Tsuchiya, Y.; Kamata, H.; Nishimura, F.; Isobe, T.; Ogihara, T.; Katagiri, H.; Oka, Y.; Takahashi, S.; Kurihara, H.; Uchida, T.; Asano, T.
    Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with insulin receptor substrate-1 and enhances insulin actions and adipogenesis (2011), J. Biol. Chem., 286, 20812-20822.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.2.1.8

Application

Application Comment Organism
medicine Pin1 is a target molecule for treating diabetes mellitus Mus musculus
medicine Pin1 is a target molecule for treating diabetes mellitus Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli JM105 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-Sepharose 4B column chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-
3T3-L1 cell
-
 Homo sapiens
-
adipocyte
-
 Homo sapiens
-
adipose tissue
-
 Mus musculus
-
liver
-
 Mus musculus
-
muscle
-
 Mus musculus
-
preadipocyte
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
peptidyl-prolyl cis/trans isomerase NIMA-interacting 1
-
 Mus musculus
peptidyl-prolyl cis/trans isomerase NIMA-interacting 1
-
 Homo sapiens
Pin1
-
 Mus musculus
Pin1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens the overexpression of Pin1 in Hep-G2 cells markedly enhances insulin-induced IRS-1 phosphorylation and its downstream events: phosphatidylinositol 3-kinase binding with IRS-1andAkt phosphorylation up
Mus musculus the overexpression of Pin1 in Hep-G2 cells markedly enhances insulin-induced IRS-1 phosphorylation and its downstream events: phosphatidylinositol 3-kinase binding with IRS-1andAkt phosphorylation. Pin1 expression is up-regulated in accordance with nutrient conditions such as food intake or a high-fat diet up

General Information

General Information Comment Organism
malfunction Pin1 knock-out mice exhibit impaired insulin signaling with glucose intolerance. Pin1 knock-out mice are resistant to diet-induced obesity Mus musculus
physiological function Pin1 plays a critical role in adipose differentiation. Pin1 binds to IRS-1 and thereby markedly enhances insulin action, essential for adipogenesis Mus musculus
physiological function Pin1 plays a critical role in adipose differentiation. Pin1 binds to IRS-1 and thereby markedly enhances insulin action, essential for adipogenesis Homo sapiens