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Literature summary for 5.2.1.8 extracted from

  • Kallscheuer, N.; Bott, M.; van Ooyen, J.; Polen, T.
    Single-domain peptidyl-prolyl cis/trans psomerase FkpA from Corynebacterium glutamicum improves the biomass yield at increased growth temperatures (2015), Appl. Environ. Microbiol., 81, 7839-7850 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
FK506 0.0005 mM, almost complete inhibition Corynebacterium glutamicum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.059
-
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum
0.104
-
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum P42458
-
-
Corynebacterium glutamicum ATCC 13032 P42458
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
-
Corynebacterium glutamicum N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
-
?
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide
-
Corynebacterium glutamicum ATCC 13032 N-succinyl-Ala-Ala-(trans)-Pro-Phe-4-nitroanilide
-
?
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide
-
Corynebacterium glutamicum N-succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilide
-
?
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide
-
Corynebacterium glutamicum ATCC 13032 N-succinyl-Ala-Leu-(trans)-Pro-Phe-4-nitroanilide
-
?

Synonyms

Synonyms Comment Organism
Cgl0830
-
Corynebacterium glutamicum
FK506-binding protein
-
Corynebacterium glutamicum
FkpA
-
Corynebacterium glutamicum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
58
-
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum
172
-
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum

General Information

General Information Comment Organism
physiological function FkpA delays the aggregation of citrate synthase in vitro and has a positive effect on the activity and temperature range of citrate synthase in vitro. Deletion of FkpA causes a 50% reduced biomass yield compared to that of the wild type when grown at 37°C, whereas there is only a 10% reduced biomass yield at the optimal growth temperature of 30°C accompanied by accumulation of 7 mM L-glutamate and 22 mM 2-oxoglutarate Corynebacterium glutamicum

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
600
-
N-succinyl-Ala-Leu-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum
1700
-
N-succinyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide pH 7.5, temperature not specified in the publication Corynebacterium glutamicum