Literature summary for 5.3.1.1 extracted from

Jiang, H.; Ma, N.; Shang, Y.; Zhou, W.; Chen, T.; Guan, D.; Li, J.; Wang, J.; Zhang, E.; Feng, Y.; Yin, F.; Yuan, Y.; Fang, Y.; Qiu, L.; Xie, D.; Wei, D.
Triosephosphate isomerase 1 suppresses growth, migration and invasion of hepatocellular carcinoma cells (2017), Biochem. Biophys. Res. Commun., 482, 1048-1053 .

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Application

Application	Comment	Organism
medicine	TPI1 expression is greatly decreased in clinical hepatocellular carcinoma samples, positively correlated with overall survival, and negatively associated with histological differentiation, tumor size and organ metastasis. Forced expression of TPI1 in hepatocellular carcinoma cells inhibits cell growth, migration, and invasion in vitro. Knockdown of TPI1 by shRNA promotes cell growth, migration and invasion. Overexpression of TPI1 leads to slowed tumor growth and decreased tumor weight in vivo. Cell cycle arrest is induced by TPI1 overexpression	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEP-3B cell	-	Homo sapiens	-
Huh-7 cell	-	Homo sapiens	-
YY-8103 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
TPI1	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	forced expression of TPI1 in hepatocellular carcinoma cells inhibits cell growth, migration, and invasion in vitro. Knockdown of TPI1 by shRNA promotes cell growth, migration and invasion. Overexpression of TPI1 leads to slowed tumor growth and decreased tumor weight in vivo. Cell cycle arrest is induced by TPI1 overexpression	Homo sapiens

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Release 2023.1 (January 2023)