Literature summary for 5.3.1.24 extracted from

Creighton, T.E.; Yanofsky, C.
Chorismate to tryptophan (Escherichia coli) - anthranilate synthethase, PR transferase; PRA isomerase, InGP synthetase, tryptophan synthetase (1970), Methods Enzymol., 17A, 365-380.

No PubMed abstract available

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0049	-	N-(5-phospho-beta-D-ribosyl)anthranilate	-	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate	Escherichia coli	third step in tryptophan biosynthesis	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?
N-(5-phospho-beta-D-ribosyl)anthranilate	Escherichia coli	involved in tryptophan biosynthesis from chorismate	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	bifunctional indole-3-glycerol-phosphate synthetase/PRA isomerase complex	-

Purification (Commentary)

Purification (Comment)	Organism
best isolated from mutant trp A2	Escherichia coli
indole-3-glycerol-phosphate synthetase/PRA isomerase complex	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-(5-phospho-beta-D-ribosyl)anthranilate	-	Escherichia coli	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?
N-(5-phospho-beta-D-ribosyl)anthranilate	third step in tryptophan biosynthesis	Escherichia coli	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?
N-(5-phospho-beta-D-ribosyl)anthranilate	involved in tryptophan biosynthesis from chorismate	Escherichia coli	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
50	-	N-(5-phospho-beta-D-ribosyl)anthranilate	-	Escherichia coli

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Release 2023.1 (January 2023)