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Literature summary for 5.3.3.8 extracted from

  • Vydra, J.; Selicharova, I.; Smutna, K.; Sanda, M.; Matouskova, E.; Burskova, E.; Prchalova, M.; Velenska, Z.; Coufal, D.; Jiracek, J.
    Two-dimensional electrophoretic comparison of metastatic and non-metastatic human breast tumors using in vitro cultured epithelial cells derived from the cancer tissues (2008), BMC Cancer, 8, 107.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine decreased levels of 2,3-trans-enoyl-CoA isomerase might have impact on the aberrant behaviour of cancer cells Homo sapiens
medicine in primary cultures of epithelial cells from 23 breast cancer tissue samples, nucleophosmin is increased in the group with metastases. The levels of 2,3-trans-enoyl-CoA isomerase and glutathione peroxidase 1 are decreased Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
determined by 2-D gel electrophoresis Homo sapiens
28000
-
theoretical Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Homo sapiens P42126
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
breast carcinoma cell
-
Homo sapiens
-
epithelium primary cultures of epithelial cells from breast cancer tissue samples Homo sapiens
-
mammary epithelial cell
-
Homo sapiens
-
primary culture primary cultures of epithelial cells from breast cancer tissue samples Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information involved in mitochondrial beta-oxidation of unsaturated fatty acids. Decreased levels of this enzyme in metastatic breast cancer cells might have impact on the aberrant behavior of cancer cells Homo sapiens ?
-
?

Subunits

Subunits Comment Organism
? x * 27000, SDS-PAGE Homo sapiens
? x * 28000, estimated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
2,3-trans-enoyl-CoA isomerase
-
Homo sapiens
3,2-trans-Enoyl-CoA isomerase
-
Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens estimated from amino acid sequence
-
6
Homo sapiens theoretical
-
6
Homo sapiens isoelectric focusing
-
6.3
Homo sapiens determined by 2-D gel electrophoresis
-
6.3

Expression

Organism Comment Expression
Homo sapiens expression of 2,3-trans-enoyl-CoA isomerase is decreased in metastatic tumor tissue down
Homo sapiens the level of 2,3-trans-enoyl-CoA isomerase is decreased in metastatic breast cancer down

General Information

General Information Comment Organism
physiological function 2,3-trans-enoyl-CoA isomerase is involved in mitochondrial beta-oxidation of unsaturated fatty acids Homo sapiens
physiological function the enzyme is involved in mitochondrial beta-oxidation of unsaturated fatty acids Homo sapiens