Literature summary for 5.3.3.8 extracted from

Rasmussen, A.L.; Diamond, D.L.; McDermott, J.E.; Gao, X.; Metz, T.O.; Matzke, M.M.; Carter, V.S.; Belisle, S.E.; Korth, M.J.; Waters, K.M.; Smith, R.D.; Katze, M.G.
Systems virology identifies a mitochondrial fatty acid oxidation enzyme, dodecenoyl coenzyme A delta isomerase, required for hepatitis C virus replication and likely pathogenesis (2011), J. Virol., 85, 11646-11654.

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Application

Application	Comment	Organism
medicine	enzyme is involved in controlling host metabolic reprogramming during hepatitis C virus infection. Hepatitis C virus growth and RNA replication in hepatoma cell lines stably expressing dodecenoyl coenzyme A delta isomerase-targeting short hairpin RNA (shRNA) are abrogated, indicating that dodecenoyl coenzyme A delta isomerase is required for productive infection. Pharmacologic inhibition of fatty acid oxidation also blocks hepatitis C virus replication. Production of infectious hepatitis C virus is restored by overexpression of an shRNA-resistant dodecenoyl coenzyme A delta isomerase allele	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli DH5alpha cells	Hepacivirus C

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	-	-	-
Homo sapiens	P42126	-	-

Synonyms

Synonyms	Comment	Organism
DCI	-	Hepacivirus C
dodecenoyl coenzyme A DELTA isomerase	-	Hepacivirus C
dodecenoyl coenzyme A DELTA isomerase	-	Homo sapiens
ECI1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	enzyme knockdown of inhibits hepatitis C virus RNA replication in cultured hepatoma cells. Enzyme deficiency causes alterations in the cellular metabolome	Hepacivirus C
physiological function	the enzyme is required for hepatitis C virus replication and likely pathogenesis	Hepacivirus C

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Release 2023.1 (January 2023)