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Literature summary for 5.4.2.8 extracted from

  • Hansen, S.H.; Frank, S.R.; Casanova, J.E.
    Cloning and characterization of human phosphomannomutase, a mammalian homologue of yeast SEC53 (1997), Glycobiology, 7, 829-834.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in a temperature-sensitive mutant sec53 yeast strain, expression in BHK cells Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
29000
-
immunoprecipitation using 9e10 antibody Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-mannose 6-phosphate Homo sapiens conversion to mannose 1-phosphate, which is a substrate for the synthesis of GDPmannose. This nucleotide sugar is then used in the synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol anchored proteins D-mannose 1-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Mannose 1-phosphate
-
Homo sapiens D-Mannose 6-phosphate
-
?
D-mannose 6-phosphate conversion to mannose 1-phosphate, which is a substrate for the synthesis of GDPmannose. This nucleotide sugar is then used in the synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of glycosyl-phosphatidyl-inositol anchored proteins Homo sapiens D-mannose 1-phosphate
-
?