Literature summary for 5.4.2.8 extracted from

Menniti, M.; Iuliano, R.; Amato, R.; Boito, R.; Corea, M.; Le Pera, I.; Gulletta, E.; Fuiano, G.; Perrotti, N.
Serum and glucocorticoid-regulated kinase Sgk1 inhibits insulin-dependent activation of phosphomannomutase 2 in transfected COS-7 cells (2005), Am. J. Physiol., 288, C148-155.

Search for more literature for 5.4.2.8

Activating Compound

Activating Compound	Comment	Organism	Structure
Insulin	incubation with insulin for 45min led to a more than twofold activation of the enzyme	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
serum- and glucocorticoid-regulated kinase	Sgk1 decreases the enzymatic activity of PMM2 in the basal state and upon insulin stimulation in intact COS-7 cells	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	expression in COS-7 cells	Homo sapiens	5737	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-mannose-1-phosphate	-	Homo sapiens	mannose-6-phosphate	-	r

Synonyms

Synonyms	Comment	Organism
PMM2	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)