Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.3.3 extracted from

  • Tang, K.H.; Mansoorabadi, S.O.; Reed, G.H.; Frey, P.A.
    Radical triplets and suicide inhibition in reactions of 4-thia-D- and 4-thia-L-lysine with lysine 5,6-aminomutase (2009), Biochemistry, 48, 8151-8160.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.3.3

Inhibitors

Inhibitors Comment Organism Structure
4-thia-D-lysine suicide inhibitor Porphyromonas gingivalis
4-thia-L-lysine suicide inhibitor Porphyromonas gingivalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(3S)-3,6-diaminohexanoate Porphyromonas gingivalis
-
 (3S,5S)-3,5-diaminohexanoate
-
 ?
D-lysine Porphyromonas gingivalis
-
 2,5-diaminohexanoate
-
 ?

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3S)-3,6-diaminohexanoate
-
 Porphyromonas gingivalis (3S,5S)-3,5-diaminohexanoate
-
 ?
4-thia-D-lysine substrate analogue, suicide inhibitor Porphyromonas gingivalis ?
-
 ?
4-thia-L-lysine substrate analogue, suicide inhibitor Porphyromonas gingivalis ?
-
 ?
D-lysine
-
 Porphyromonas gingivalis 2,5-diaminohexanoate
-
 ?
D-lysine
-
 Porphyromonas gingivalis D-2,5-diaminohexanoate
-
 ?
L-beta-lysine
-
 Porphyromonas gingivalis L-3,5-diaminohexanoate
-
 ?
L-lysine
-
 Porphyromonas gingivalis L-2,5-diaminohexanoate
-
 ?

Subunits

Subunits Comment Organism
heterotetramer alpha2beta2 Porphyromonas gingivalis

Synonyms

Synonyms Comment Organism
5,6-LAM
-
 Porphyromonas gingivalis
lysine 5,6-aminomutase
-
 Porphyromonas gingivalis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 enzyme assay Porphyromonas gingivalis

Cofactor

Cofactor Comment Organism Structure
5'-deoxyadenosylcobalamin
-
 Porphyromonas gingivalis
pyridoxal 5'-phosphate
-
 Porphyromonas gingivalis

General Information

General Information Comment Organism
metabolism lysine 5,6-aminomutase participates in the fermentation of L- or D-lysine as carbon and nitrogen sources in anaerobic bacteria Porphyromonas gingivalis