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Literature summary for 5.4.3.5 extracted from

  • Wolthers, K.R.; Levy, C.; Scrutton, N.S.; Leys, D.
    Large-scale domain dynamics and adenosylcobalamin reorientation orchestrate radical catalysis in ornithine 4,5-aminomutase (2010), J. Biol. Chem., 285, 13942-13950.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.4.3.5

Cloned(Commentary)

Cloned (Comment) Organism
for expression in Escherichia coli cells Acetoanaerobium sticklandii

Crystallization (Commentary)

Crystallization (Comment) Organism
the structure of substrate-free ornithine 4,5-aminomutase is solved to a resolution of 2.0 A, furthermore the structures of the enzyme in complex with D-ornithine and in complex with the inhibitor 2,4-diaminobutyrate are determined Acetoanaerobium sticklandii

Inhibitors

Inhibitors Comment Organism Structure
2,4-diaminobutyrate
-
 Acetoanaerobium sticklandii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
12800
-
 OraS Acetoanaerobium sticklandii
12800
-
 alpha2beta2, OraS, OraE, 2 * 12800 + 2 * 82900 Acetoanaerobium sticklandii
82900
-
 OraE Acetoanaerobium sticklandii
82900
-
 alpha2beta2, OraS, OraE, 2 * 12800 + 2 * 82900 Acetoanaerobium sticklandii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-ornithine Acetoanaerobium sticklandii
-
 (2R,4S)-2,4-diaminopentanoate
-
 ?

Organism

Organism UniProt Comment Textmining
Acetoanaerobium sticklandii E3PY95
-
-
Acetoanaerobium sticklandii E3PY96
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Acetoanaerobium sticklandii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-ornithine
-
 Acetoanaerobium sticklandii (2R,4S)-2,4-diaminopentanoate
-
 ?

Subunits

Subunits Comment Organism
heterotetramer alpha2beta2, OraS, OraE, 2 * 12800 + 2 * 82900 Acetoanaerobium sticklandii

Synonyms

Synonyms Comment Organism
OAM
-
 Acetoanaerobium sticklandii
oraE
-
 Acetoanaerobium sticklandii
oraS
-
 Acetoanaerobium sticklandii
ornithine 4,5-aminomutase
-
 Acetoanaerobium sticklandii

Cofactor

Cofactor Comment Organism Structure
adenosylcobalamin
-
 Acetoanaerobium sticklandii
pyridoxal 5'-phosphate
-
 Acetoanaerobium sticklandii