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Literature summary for 5.4.3.8 extracted from
- Intersubunit signaling in glutamate-1-semialdehyde-aminomutase (2006), Proc. Natl. Acad. Sci. USA, 103, 13688-13693.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Synechococcus sp. |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Synechococcus sp. |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Synechococcus sp. | P24630 | - |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-glutamate 1-semialdehyde = 5-aminolevulinate | enzyme shows an active-site gating loop, which undergoes a dramatic conformational change during catalysis, that is simultaneously open in one subunit and closed in the other. Loop movement requires a beta-sheet-to-alpha-helix transition to assume the closed conformation, thus facilitating transport of substrate toward, and concomitantly forming, an integral part of the active site. The accompanying intersubunit cross-talk controls negative cooperativity between the allosteric pair | Synechococcus sp. |
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Release 2023.1 (January 2023)
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