Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 5.4.99.17 extracted from

  • Cravotto, G.; Balliano, G.; Tagliapietra, S.; Palmisano, G.; Penoni, A.
    Umbelliferone aminoalkyl derivatives, a new class of squalene-hopene cyclase inhibitors (2004), Eur. J. Med. Chem., 39, 917-924.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Alicyclobacillus acidocaldarius

Inhibitors

Inhibitors Comment Organism Structure
3-(10'-(allylmethylamino)decanoyl)chroman-2,4-dione IC50 100 microMol Alicyclobacillus acidocaldarius
7-(10'-(dimethylamino-N-decyloxy))chromen-2-one IC50 5 microMol Alicyclobacillus acidocaldarius
7-(10-(allylmethylamino)-decyloxy)chromen-2-one IC50 2 microMol Alicyclobacillus acidocaldarius
7-(4'-(N,N,N'-trimethylethylendiamino)-but-2-ynyloxy)chromen-2-one not active at 100 microMol Alicyclobacillus acidocaldarius
7-(4'-(N-diethylamino)-but-2-ynyloxy)chromen-2-one IC50 5 microMol Alicyclobacillus acidocaldarius
7-(4'-(N-pyrrolidyn)-but-2-ynyloxy)chromen-2-one IC50 5 microMol Alicyclobacillus acidocaldarius
7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one IC50 0.75 microMol Alicyclobacillus acidocaldarius
7-(6'-(benzylamino-hexyloxy))chromen-2-one IC50 8 microMol Alicyclobacillus acidocaldarius
7-(6-(allylmethylamino)-hexyloxy)chromen-2-one IC50 4-5 microMol Alicyclobacillus acidocaldarius
7-(8'-(dimethylamino-N-octyloxy))chromen-2-one IC50 5-7 microMol Alicyclobacillus acidocaldarius
7-(morpholinyl-N-hexyloxy)chromen-2-one IC50 6 microMol Alicyclobacillus acidocaldarius
7-(morpholinyl-N-octyloxy)chromen-2-one IC50 7 microMol Alicyclobacillus acidocaldarius
7-(piperidinyl-N-hexyloxy)chromen-2-one IC50 8 microMol Alicyclobacillus acidocaldarius
Ro 48-8071 IC50 0.35 microMol Alicyclobacillus acidocaldarius

Organism

Organism UniProt Comment Textmining
Alicyclobacillus acidocaldarius
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
squalene
-
Alicyclobacillus acidocaldarius ?
-
?

Synonyms

Synonyms Comment Organism
SHC
-
Alicyclobacillus acidocaldarius

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00035
-
IC50 0.35 microMol Alicyclobacillus acidocaldarius Ro 48-8071
0.00075
-
IC50 0.75 microMol Alicyclobacillus acidocaldarius 7-(4-allylmethylamino-but-2-ynyloxy)chromen-2-one
0.002
-
IC50 2 microMol Alicyclobacillus acidocaldarius 7-(10-(allylmethylamino)-decyloxy)chromen-2-one
0.004 0.005 IC50 4-5 microMol Alicyclobacillus acidocaldarius 7-(6-(allylmethylamino)-hexyloxy)chromen-2-one
0.005
-
IC50 5 microMol Alicyclobacillus acidocaldarius 7-(4'-(N-pyrrolidyn)-but-2-ynyloxy)chromen-2-one
0.005
-
IC50 5 microMol Alicyclobacillus acidocaldarius 7-(4'-(N-diethylamino)-but-2-ynyloxy)chromen-2-one
0.005
-
IC50 5 microMol Alicyclobacillus acidocaldarius 7-(10'-(dimethylamino-N-decyloxy))chromen-2-one
0.005 0.007 IC50 5-7 microMol Alicyclobacillus acidocaldarius 7-(8'-(dimethylamino-N-octyloxy))chromen-2-one
0.006
-
IC50 6 microMol Alicyclobacillus acidocaldarius 7-(morpholinyl-N-hexyloxy)chromen-2-one
0.007
-
IC50 7 microMol Alicyclobacillus acidocaldarius 7-(morpholinyl-N-octyloxy)chromen-2-one
0.008
-
IC50 8 microMol Alicyclobacillus acidocaldarius 7-(piperidinyl-N-hexyloxy)chromen-2-one
0.008
-
IC50 8 microMol Alicyclobacillus acidocaldarius 7-(6'-(benzylamino-hexyloxy))chromen-2-one
0.1
-
IC50 100 microMol Alicyclobacillus acidocaldarius 3-(10'-(allylmethylamino)decanoyl)chroman-2,4-dione