Inhibitors | Comment | Organism | Structure |
---|---|---|---|
NEM | - |
Mammalia | |
p-hydroxymercuribenzoate | - |
Mammalia |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0345 | - |
succinyl-CoA | - |
Propionibacterium freudenreichii subsp. shermanii | |
0.062 | - |
succinyl-CoA | - |
Ovis aries | |
0.085 | - |
(R)-2-methyl-3-oxopropanoyl-CoA | - |
Propionibacterium freudenreichii subsp. shermanii | |
0.24 | - |
(R)-2-methyl-3-oxopropanoyl-CoA | - |
Ovis aries |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
61000 | - |
1 * 61000 + 1 * 66000, SDS-PAGE | Propionibacterium freudenreichii subsp. shermanii |
66000 | - |
1 * 61000 + 1 * 66000, SDS-PAGE | Propionibacterium freudenreichii subsp. shermanii |
122000 | 124000 | gel filtration, calculation from sedimentation and diffusion data | Propionibacterium freudenreichii subsp. shermanii |
165000 | - |
determination from sedimentation data | Ovis aries |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-2-Methyl-3-oxopropanoyl-CoA | Ovis aries | key position in metabolism of propionic acid | ? | - |
? | |
Succinyl-CoA | Propionibacterium freudenreichii subsp. shermanii | production of propionate from succinate | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Ovis aries | - |
- |
- |
Propionibacterium freudenreichii subsp. shermanii | - |
strain 52W and strain St 33 | - |
Purification (Comment) | Organism |
---|---|
- |
Ovis aries |
- |
Propionibacterium freudenreichii subsp. shermanii |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(R)-methylmalonyl-CoA = succinyl-CoA | mechanism | Ovis aries | |
(R)-methylmalonyl-CoA = succinyl-CoA | mechanism | Propionibacterium freudenreichii subsp. shermanii |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Ovis aries | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Ovis aries |
additional information | - |
- |
Propionibacterium freudenreichii subsp. shermanii |
Storage Stability | Organism |
---|---|
-10°C, enzyme from strain 52 W is quite stable, the enzyme from strain St 33 is much less so | Propionibacterium freudenreichii subsp. shermanii |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-2-Methyl-3-oxopropanoyl-CoA | - |
Propionibacterium freudenreichii subsp. shermanii | ? | - |
? | |
(R)-2-Methyl-3-oxopropanoyl-CoA | key position in metabolism of propionic acid | Ovis aries | ? | - |
? | |
(R)-2-methylmalonyl-CoA | - |
Mammalia | succinyl-CoA | - |
? | |
(R)-2-methylmalonyl-CoA | - |
Ovis aries | succinyl-CoA | - |
? | |
(R)-2-methylmalonyl-CoA | - |
Propionibacterium freudenreichii subsp. shermanii | succinyl-CoA | - |
? | |
Succinyl-CoA | production of propionate from succinate | Propionibacterium freudenreichii subsp. shermanii | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 1 * 61000 + 1 * 66000, SDS-PAGE | Propionibacterium freudenreichii subsp. shermanii |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Ovis aries |
7.4 | - |
- |
Propionibacterium freudenreichii subsp. shermanii |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
Coalpha(alpha-Benzimidazolyl)-Cobeta-adenosyl-cobamide | can serve as coenzyme | Propionibacterium freudenreichii subsp. shermanii | |
Coalpha-(alpha-Purinyl)-Cobeta-adenosylcobamide | can serve as coenzyme | Propionibacterium freudenreichii subsp. shermanii | |
Coalpha-Hydroxo-Cobeta-adenosylcobinamide | can serve as coenzyme | Propionibacterium freudenreichii subsp. shermanii | |
Coalpha[alpha-(Aden-7-yl)]-Cobeta-adenosyl-cobamide | can serve as coenzyme | Propionibacterium freudenreichii subsp. shermanii | |
cobamide | - |
Mammalia | |
cobamide | adenosylcobalamin protects the apoenzyme from inactivation by NEM or iodoacetamide. Km: 0.000021 mM | Ovis aries | |
cobamide | one molecule of enzyme contains about 2 molecules of adenosylcobalamin | Ovis aries | |
cobamide | Km: 0.000035 mM | Propionibacterium freudenreichii subsp. shermanii |