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Literature summary for 5.4.99.5 extracted from
- Pericyclic reactions catalyzed by chorismate-utilizing enzymes (2011), Biochemistry, 50, 7476-7483.
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | chorismate mutase activity is only detected when the Mg2+ is not present in the wild-type active site | Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Chorismate | Pseudomonas aeruginosa | - |
Prephenate | - |
? |  |
| additional information | Pseudomonas aeruginosa | isochorismate-pyruvate lyase, PchB EC 4.2.99.21, can also perform the chorismate mutase reaction | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| Chorismate = prephenate | via near attack conformation and transition state intermediates, reaction mechanism, overview | Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Chorismate | - |
Pseudomonas aeruginosa | Prephenate | - |
? | |
| additional information | isochorismate-pyruvate lyase, PchB EC 4.2.99.21, can also perform the chorismate mutase reaction | Pseudomonas aeruginosa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme structure comparisons of isochorismate-pyruvate lyase, PchB, with chorismate mutases, overview | Pseudomonas aeruginosa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | structure-function relationships of chorismate-utilizing enzymes, structure comparisons, overview | Pseudomonas aeruginosa |
| physiological function | isochorismate-pyruvate lyase, PchB EC 4.2.99.21, can also perform a nonphysiological role as a chorismate mutase albeit with considerably lower catalytic efficiency | Pseudomonas aeruginosa |
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Release 2023.1 (January 2023)
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