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Literature summary for 5.5.1.6 extracted from

  • Chemler, J.A.; Yan, Y.; Leonard, E.; Koffas, M.A.
    Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms (2007), Org. Lett., 9, 1855-1858.
    View publication on PubMed
Search for more literature for 5.5.1.6

Application

Application Comment Organism
synthesis combinatorial expression of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase in Saccharomyces cerevisiae for production of unnatural flavanones when fed with aromatic acrylic acids Scutellaria baicalensis

Cloned(Commentary)

Cloned (Comment) Organism
combinatorial expression of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase in Saccharomyces cerevisiae Scutellaria baicalensis

Organism

Organism UniProt Comment Textmining
Scutellaria baicalensis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E)-3-(2-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(2-fluorophenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2R)-2-(2-fluorophenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one
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 ?
(2E)-3-(2-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(2-hydroxyphenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2R)-5,7-dihydroxy-2-(2-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
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 ?
(2E)-3-(3-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(3-hydroxyphenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2R)-5,7-dihydroxy-2-(3-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
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 ?
(2E)-3-(4-aminophenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(4-aminophenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2R)-2-(4-aminophenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one
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 ?
(2E)-3-(4-fluorophenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(4-fluorophenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2R)-2-(4-fluorophenyl)-5,7-dihydroxy-2,3-dihydro-4H-chromen-4-one
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 ?
(2E)-3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one based on substrate (2E)-3-(4-hydroxyphenyl)acrylic acid in combinatorial expression system of 4-coumaroyl:Co A ligase, chalcone synthase, chalcone isomerase, and flavanone 3beta-hydrolase Scutellaria baicalensis (2S)-5,7-dihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chromen-4-one
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 ?