Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5'-adenylylimidodiphosphate | - |
Homo sapiens | |
N-ethylmaleimide | - |
Homo sapiens | |
VO43- | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
cytoplasm | - |
Dictyostelium sp. | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
31200 | - |
calculated from predicted amino acid sequence | Homo sapiens |
87400 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n | Homo sapiens | - |
ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | Xenopus laevis | - |
ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | Dictyostelium sp. | - |
ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dictyostelium sp. | - |
- |
- |
Homo sapiens | - |
human, HeLa cells | - |
Xenopus laevis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
partially | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules | Homo sapiens | |
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules | Xenopus laevis | |
ATP + H2O + a kinesin associated with a microtubule at position n = ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | structurally almost identical to EC3.6.4.3 (microtubule-severing ATPase) but the movement it catalyses is towards the minus end of microtubules | Dictyostelium sp. |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
egg | - |
Xenopus laevis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2',3'-dideoxy-ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | 2',3'-dideoxy-ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Homo sapiens | ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Xenopus laevis | ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
ATP + H2O + a kinesin associated with a microtubule at position n | - |
Dictyostelium sp. | ADP + phosphate + a kinesin associated with a microtubule at position n-1 (toward the minus end) | - |
? | |
additional information | GTP, 8-bromo ATP, 1,N6-etheno-adenosine 5'-triphosphate and 5'-O-(3-thiotriphosphate) are no substrates | Homo sapiens | ? | - |
? |