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Literature summary for 5.6.2.1 extracted from

  • Andersen, A.H.; Bendixen, C.; Westergaard, O.
    DNA topoisomerases (1996), DNA Replication in eucaryotic cells, Cold Spring Harbor Laboratory Press, , 587-617.
No PubMed abstract available
Search for more literature for 5.6.2.1

Activating Compound

Activating Compound Comment Organism Structure
additional information enzyme is posttranslationally modified and presumably regulated by phosphorylation eukaryota

Inhibitors

Inhibitors Comment Organism Structure
camptothecins
-
 eukaryota
camptothecins
-
 Vaccinia virus
topotecan
-
 eukaryota

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ no requirement for Mg2+ eukaryota
Mg2+ no requirement for Mg2+ Vaccinia virus
Mg2+ no requirement for Mg2+ Rabbit fibroma virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information eukaryota enzyme controls the topological state of DNA ?
-
 ?
additional information Vaccinia virus enzyme controls the topological state of DNA ?
-
 ?
additional information Rabbit fibroma virus enzyme controls the topological state of DNA ?
-
 ?
additional information eukaryota plays a role in transcriptional elongation ?
-
 ?
additional information eukaryota plays a crucial role in controlling the physiological functions of DNA ?
-
 ?
additional information eukaryota plays a direct role in the regulation of transcriptional initiation by acting as a repressor of the basal-level transcription ?
-
 ?

Organism

Organism UniProt Comment Textmining
eukaryota
-
-
-
Rabbit fibroma virus
-
-
-
Vaccinia virus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining acts by directing a nucleophilic attack from the hydroxyl group of an internal Tyr into a phosphodiester bond in the DNA backbone, resulting in nicking of one strand of the DNA double helix and formation of a covalent linkage between the 3'-phosphate and the Tyr hydroxyl group eukaryota
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme controls the topological state of DNA eukaryota ?
-
 ?
additional information enzyme controls the topological state of DNA Vaccinia virus ?
-
 ?
additional information enzyme controls the topological state of DNA Rabbit fibroma virus ?
-
 ?
additional information plays a role in transcriptional elongation eukaryota ?
-
 ?
additional information plays a crucial role in controlling the physiological functions of DNA eukaryota ?
-
 ?
additional information plays a direct role in the regulation of transcriptional initiation by acting as a repressor of the basal-level transcription eukaryota ?
-
 ?
supercoiled DNA rather weak sequence specificity eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA rather weak sequence specificity Vaccinia virus relaxed closed circular DNA
-
 ?
supercoiled DNA rather weak sequence specificity Rabbit fibroma virus relaxed closed circular DNA
-
 ?
supercoiled DNA when oligonucleotide DNA duplexes are used as substrates, the generated cleavage complex contains an active enzyme, which is able to ligate the cleaved DNA to a variety of DNA fragments containing a free 5'-OH end Vaccinia virus relaxed closed circular DNA
-
 ?
supercoiled DNA single-strand of DNA double helix eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA single-strand of DNA double helix Vaccinia virus relaxed closed circular DNA
-
 ?
supercoiled DNA single-strand of DNA double helix Rabbit fibroma virus relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation Vaccinia virus relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation Rabbit fibroma virus relaxed closed circular DNA
-
 ?