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Literature summary for 5.6.2.1 extracted from

  • Sutcliffe, J.A.; Gootz, T.D.; Barrett, J.F.
    Biochemical characteristics and physiological significance of major DNA topoisomerases (1989), Antimicrob. Agents Chemother., 33, 2027-2033.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Bacteria
Mg2+ required Escherichia coli
Mg2+ no requirement for Mg2+ eukaryota

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
97410
-
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information eukaryota
-
 ?
-
 ?
additional information Escherichia coli
-
 ?
-
 ?
additional information Bacteria topoisomerase I works in concert with topoisomerase II to modulate the level of DNA supercoiling ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-
Escherichia coli
-
-
-
eukaryota
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information
-
 eukaryota ?
-
 ?
additional information
-
 Escherichia coli ?
-
 ?
additional information enzyme becomes covalently linked to the 3'-phosphoryl group, when it cleaves DNA eukaryota ?
-
 ?
additional information topoisomerase I works in concert with topoisomerase II to modulate the level of DNA supercoiling Bacteria ?
-
 ?
supercoiled DNA relaxation Salmonella enterica subsp. enterica serovar Typhimurium relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation Bacteria relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA relaxation Escherichia coli relaxed closed circular DNA
-
 ?
supercoiled DNA positive and negative supercoiled DNA eukaryota relaxed closed circular DNA
-
 ?
supercoiled DNA specific for negatively supercoiled DNA, no activity with positively supercoiled DNA Bacteria relaxed closed circular DNA
-
 ?
supercoiled DNA specific for negatively supercoiled DNA, no activity with positively supercoiled DNA Escherichia coli relaxed closed circular DNA
-
 ?