Literature summary for 5.6.2.1 extracted from

Ikegami, Y.; Takeuchi, N.; Hanada, M.; Hasegawa, Y.; Ishi, K.; Andoh, T.; Sato, T.; Suzuki, K.; Yamaguchi, H.; Miyazaki, S.; Nagai, K.; Watanabe, S.; Saito, T.
Topostin, a novel inhibitor of mammalian DNA topoisomerase I from Flexibacter topostinus sp. nov.. II. Purification and some properties of topostin (1990), J. Antibiot., 43, 158-162.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Topostin B-553	interacts primarily with the enzyme and not with the substrate DNA	Mus musculus
Topostin B-567	interacts primarily with the enzyme and not with the substrate DNA	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Ehrlich ascites carcinoma cell	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA	relaxation	Mus musculus	relaxed closed circular DNA	-	?

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Release 2023.1 (January 2023)