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Literature summary for 5.6.2.1 extracted from
- Purification and nuclear localization of a type I topoisomerase from Crithidia fasciculata (1987), Mol. Biochem. Parasitol., 24, 215-225.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Berenil | - |
Crithidia fasciculata |  |
| Ethidium bromide | - |
Crithidia fasciculata | |
| NEM | - |
Crithidia fasciculata | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| nucleus | - |
Crithidia fasciculata | 5634 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | no requirement for divalent cation but 10fold to 20fold stimulation by the presence of MgCl2 | Crithidia fasciculata | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 79000 | - |
glycerol density gradient sedimentation | Crithidia fasciculata |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Crithidia fasciculata | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Crithidia fasciculata |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Crithidia fasciculata |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Crithidia fasciculata | relaxed closed circular DNA | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 79000, SDS-PAGE | Crithidia fasciculata |
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