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Literature summary for 5.6.2.1 extracted from
- DNA topoisomerase I from rice: enzyme synthesis in germination, and partial purification from cultured cells (1991), Phytochemistry, 30, 3885-3887.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Berenil | - |
Oryza sativa |  |
| camptothecins | no inhibition | Oryza sativa | |
| coumermycin | weak | Oryza sativa | |
| Dextran sulfate | - |
Oryza sativa | |
| diethyl dicarbonate | - |
Oryza sativa | |
| EDTA | - |
Oryza sativa | |
| Ethidium bromide | no inhibition | Oryza sativa | |
| heparin | - |
Oryza sativa | |
| Na+ | above 100 mM | Oryza sativa | |
| novobiocin | weak | Oryza sativa | |
| PCMB | - |
Oryza sativa | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Na+ | maximal activity at 75 mM | Oryza sativa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
gel filtration | Oryza sativa |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryza sativa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Oryza sativa |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| seed | - |
Oryza sativa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Oryza sativa | relaxed closed circular DNA | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | - |
- |
Oryza sativa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 9.5 | 50% of maximal activity at pH 5.5 and pH 9.5 | Oryza sativa |
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Release 2023.1 (January 2023)
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