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Literature summary for 5.6.2.1 extracted from
- Identification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicans (1995), Antimicrob. Agents Chemother., 39, 586-592.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aminocatechol A-3253 | Candida enzyme is more susceptible than the human enzyme | Candida albicans |  |
| Aminocatechol A-3253 | Candida enzyme is more susceptible than the human enzyme | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Candida albicans | - |
- |
- |
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Homo sapiens | relaxed closed circular DNA | - |
? | |
| supercoiled DNA | relaxation | Candida albicans | relaxed closed circular DNA | - |
? | |
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