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Literature summary for 5.6.2.1 extracted from

  • Ting, C.Y.; Hsu, C.T.; Hsu, H.T.; Su, J.S.; Chen, T.Y.; Tarn, W.Y.; Kuo, Y.H.; Whang-Peng, J.; Liu, L.F.; Hwang, J.
    Isodiospyrin as a novel human DNA topoisomerase I inhibitor (2003), Biochem. Pharmacol., 66, 1981-1991.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
isodiospyrin inhibits by direct binding to htopo I, inhibits relexation activity and kinase activity, antagonizes camptothecin-induced DNA cleavage by htopo I Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SF2/ASF protein + ATP kinase activity Homo sapiens ?
-
?
supercoiled plasmid DNA pGEM-5T relaxation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
htopo I
-
Homo sapiens