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Literature summary for 5.6.2.1 extracted from

  • Gao, R.; Zhang, Y.; Choudhury, A.K.; Dedkova, L.M.; Hecht, S.M.
    Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine (2005), J. Am. Chem. Soc., 127, 3321-3331.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information modification of vaccinia topoisomerase I at the active site tyrosine (position 274) with several tyrosine analogues. These analogues have varied steric, electronic, and stereochemical features to permit assessment of those structural elements required to support topoisomerase function. Eleven tyrosine analogues are successfully incorporated into the active site of vaccinia topoisomerase I. It is found that only tyrosine analogues having the phenolic -OH group in the normal position relative to the protein backbone are active. Modifications that replace the nucleophilic tyrosine OH group with NH2, SH, or I groups or that changed the orientation of the nucleophilic OH group essentially eliminate topoisomerase I function Vaccinia virus

Organism

Organism UniProt Comment Textmining
Vaccinia virus
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Synonyms

Synonyms Comment Organism
type IB topoisomerase
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 Vaccinia virus