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Literature summary for 5.6.2.1 extracted from
- Antitumour drugs impede DNA uncoiling by topoisomerase I (2007), Nature, 448, 213-217.
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | topoisomerasedrug interactions for clinical development of chemotherapeutics | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| Saccharomyces cerevisiae strains EKY2 (MATa, top1D) and EKY3(MATa, top1D) | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| G365C | camptothecin-resistant Top1(G365C) mutant | Homo sapiens |
| Y723F | catalytically inactive TOP1(Y723F) | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| camptothecin | Camptothecin poisoning of TopIB induces accumulation of positively supercoiled DNA in G1- and S-phase yeast cells. Mechanism of camptothecin-induced toxicity derives from TopIB-dependent accumulation of positive supercoils | Homo sapiens |  |
| topotecan | Camptothecin analogue, induce cell death by poisoning DNA topoisomerase I, topotecan significantly hinders topoisomerase-mediated DNA uncoiling, with a more pronounced effect on the removal of positive (overwound) versus negative supercoils. Significant activity against adult and paediatric solid tumours | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA topoisomerase I | - |
Homo sapiens |
| TopIB | - |
Homo sapiens |
| Topoisomerase I | - |
Homo sapiens |
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