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Literature summary for 5.6.2.1 extracted from
- The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant (2006), Nucleic Acids Res., 34, 5093-5100.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| EKY3 yeast cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A653P | known to be CPT resistant | Homo sapiens |
| E418K | the active site tyrosine. The Glu418Lys mutant is active and partially resistant to CPT in yeast cells expressed in yeast cells, display a camptothecin resistance that slowly decreases as a function of time | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| camptothecin | when CPT is added the cleavage religation equilibrium is shifted toward cleavage | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Topoisomerase I | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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